Does folic acid act differently in the body than natural folate? | Masterjohn Q&A Files #68

<p>Question: Does folic acid act differently in the body than natural folate? | Masterjohn Q&A Files #68<br /><br />They don't really. Everything that is said bad about folic acid is sort of true to an extent but has been completely exaggerated in some circles. What happens is you have an enzyme called dihydrofolate reductase, or DHFR. Its purpose is not to metabolize synthetic folic acid obviously because that folic acid molecule doesn't exist in the food supply. Its normal purpose is that every time that you use folate to participate in processes outside of methylation, such as DNA synthesis...