If I use SAMe for depression, what do I need for nutritional balance? | Masterjohn Q&A Files #135

<p>Question: If I use SAMe for depression, what do I need for nutritional balance?<br /></p> <p>Nutrition wise, I think the most important thing would be to make sure that you have an adequate glycine status. And you know, I don't know what your background is in terms of other issues, but the glycine buffer system, which is how you buffer excess methyl groups, which is what you would have if you take a large bolus of SAMe.<br /><br />Other nutritional concern would be having enough molybdenum. Generally, you're gonna have enough with 100 mcg a day. If...